The Hebrew University in Jerusalem stands to benefit from the latest sale.
The internet and rising rent take their toll on West Side Judaica, which has been around since the 1930s.
Thousands attended the funeral of the three terrorists who killed two Israeli police.
An owner of the shop cited financial reasons in explaining the closure.
"Knocked Up" and "Superbad," which came out just a few months apart from each other, had lasting effects on Hollywood comedy.